Synephrine, Octopamine and Caffeine Health Risk Assessment (HRA) Report
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چکیده
Issue Assessment of the potential risks to health from natural health products containing synephrine and/or octopamine in combination with caffeine. various products not licensed for sale in Canada Type of Product Natural Health Products Common Name (if any) various Medicinal/Active Ingredient(s) Synephrine and/or Octopamine and Caffeine Dosage Form(s) various Strength(s) various Route of Administration Oral Proposed Indication(s) Weight loss aid is the primary indication Proposed Sub-population(s) Adults Non-medicinal/active Ingredient(s) (if applicable) various Manufacturer/Sponsor various Manufacturer Site Licence Information and Number (if applicable) various
منابع مشابه
Health assessment of sports and weight loss products containing synephrine and caffeine
Synephrine is a plant constituent which is found, for example, in bitter oranges (Citrus aurantium) and which is chemically related to ephedrine. Some products offered as sports and weight loss supplements contain synephrine in the form of added bitter orange extract. Often such products contain caffeine and other active ingredients. They are sometimes referred to by manufacturers as food suppl...
متن کاملCoronary spasm and thrombosis in a bodybuilder using a nutritional supplement containing synephrine, octopamine, tyramine and caffeine.
372 14. Lin JL, Lin-tan DT, Chen KH, et al. Repeat pulse of methylprednisolone and cyclophosphamide with continuous dexamethasone therapy for patients with severe paraquat poisoning. Crit Care Med 2006; 34(2): 368-373. 15. Lin NC, Lin JL, Lin-Tan DT. Combined initial cyclophosphamide with repeated methylprednisolone pulse therapy for severe paraquat poisoning from dermal exposure. J Toxicol Cli...
متن کاملSeville (sour) orange juice: synephrine content and cardiovascular effects in normotensive adults.
The Seville orange extract Citrus aurantium contains m-synephrine (phenylephrine) and octopamine; it causes cardiac disturbances in animals and is used by humans for weight loss. Juice from the orange (Seville orange juice [SOJ]) is used to "knock out" intestinal cytochrome P450 (CYP) 3A4 in bioavailability studies. The purpose of this study was to determine synephrine and octopamine concentrat...
متن کاملBitter Orange (Citrus aurantium var. amara) Extracts and Constituents (±)-p-Synephrine [CAS No. 94-07-5] and (±)-p-Octopamine [CAS No. 104-14-3] Review of Toxicological Literature
.......................................................................................................................................... i Executive Summary...................................................................................................................... ii 1.0 Basis for Nomination ...............................................................................................
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